植物血凝素在兽医临床上的研究应用

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<TD id=content9 vAlign=center><STRONG style="FONT-SIZE: 14px">植物血凝素在兽医临床上的研究应用　<IMG src="http://blog.35941.com/images/jhinfo.gif"></STRONG></TD></TR>
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<DIV align=right><SPAN class=textbox-label>[ 2008-8-13 22:42:00 | By: <SPAN class=style3>陈中</SPAN> ]</SPAN></DIV></TD></TR></TBODY></TABLE>
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<DIV class=MsoNormal style="MARGIN: 0cm 0cm 0pt"><SPAN style="FONT-SIZE: 12pt"><SPAN style="COLOR: black; FONT-FAMILY: 宋体; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt">植物血凝素是一种从红芸豆中提取的有丝分裂原，作为一种低聚糖与蛋白质的复合物，植物血凝素有促进淋巴细胞有丝分裂、激活免疫细胞</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Times New Roman; mso-bidi-font-size: 10.5pt">———</SPAN><SPAN style="COLOR: black; FONT-FAMILY: 宋体; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt">淋巴细胞的作用。据美国《科学》杂志报道，机体免疫系统通过识别植物血凝素而识别病毒，并产生相应的抗体和其他免疫反应，以从体内清除病毒。植物血凝素与黄芪多糖等多种中草药联用具有增效作用</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Times New Roman; mso-bidi-font-size: 10.5pt">,</SPAN><SPAN style="COLOR: black; FONT-FAMILY: 宋体; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt">与部分抗生素联用具有相加作用。因其强大的增强机体非特异性免疫力的作用以及强效的抗病毒作用，植物血凝素在兽药中的应用也日益广泛。本文对植物血凝素的抗病毒机理、增强免疫作用机理及其在兽药中的研究应用现状及应用前景做一叙述，希望能对相关药物的研究开发起到一定的促进作用。</SPAN></SPAN><SPAN lang=EN-US style="COLOR: black; mso-bidi-font-size: 10.5pt"><BR></SPAN><SPAN style="FONT-SIZE: 12pt; COLOR: black; FONT-FAMILY: 宋体; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt"></SPAN></DIV>
<DIV class=MsoNormal style="MARGIN: 0cm 0cm 0pt"><SPAN style="FONT-SIZE: 12pt; COLOR: black; FONT-FAMILY: 宋体; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt"></SPAN>&nbsp;</DIV>
<DIV class=MsoNormal style="MARGIN: 0cm 0cm 0pt"><SPAN style="FONT-SIZE: 12pt; COLOR: black; FONT-FAMILY: 宋体; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt">抗病毒机理</SPAN><SPAN lang=EN-US style="COLOR: black; mso-bidi-font-size: 10.5pt"><BR></DIV></SPAN><SPAN style="FONT-SIZE: 12pt"><SPAN style="COLOR: black; FONT-FAMILY: 宋体; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt"></SPAN></SPAN>
<DIV class=MsoNormal style="MARGIN: 0cm 0cm 0pt"><SPAN style="FONT-SIZE: 12pt"><SPAN style="COLOR: black; FONT-FAMILY: 宋体; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt">植物血凝素高效广谱的抗病毒作用，源于其能特异性的阻断病毒与宿主细胞的结合，即病毒进入宿主机体后，病毒黏附蛋白</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Times New Roman; mso-bidi-font-size: 10.5pt">(VAP)</SPAN><SPAN style="COLOR: black; FONT-FAMILY: 宋体; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt">首先与宿主靶细胞膜特异受体结合，被吸附到宿主敏感细胞上，然后通过膜融合等方式侵入细胞中，完成脱囊膜或脱壳并进行复制、转录及装配等增殖过程。植物血凝素既可以特异性与病毒黏附结合，也可以与靶细胞上的特异病毒受体结合，从而阻断病毒与细胞的黏附，使病毒无法进入细胞</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Times New Roman; mso-bidi-font-size: 10.5pt">,</SPAN><SPAN style="COLOR: black; FONT-FAMILY: 宋体; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt">以达到抗病毒抗感染的目的。同时，机体免疫系统通过识别植物血凝素而识别病毒</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Times New Roman; mso-bidi-font-size: 10.5pt">,</SPAN><SPAN style="COLOR: black; FONT-FAMILY: 宋体; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt">并产生相应的抗体和其他免疫反应</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Times New Roman; mso-bidi-font-size: 10.5pt">,</SPAN><SPAN style="COLOR: black; FONT-FAMILY: 宋体; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt">以从体内清除病毒。此外植物血凝素刺激</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Times New Roman; mso-bidi-font-size: 10.5pt">T</SPAN><SPAN style="COLOR: black; FONT-FAMILY: 宋体; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt">淋巴细胞增殖分化，产生大量效应</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Times New Roman; mso-bidi-font-size: 10.5pt">T</SPAN><SPAN style="COLOR: black; FONT-FAMILY: 宋体; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt">细胞和细胞毒</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Times New Roman; mso-bidi-font-size: 10.5pt">T</SPAN><SPAN style="COLOR: black; FONT-FAMILY: 宋体; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt">细胞，效应</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Times New Roman; mso-bidi-font-size: 10.5pt">T</SPAN><SPAN style="COLOR: black; FONT-FAMILY: 宋体; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt">细胞分泌产生大量细胞因子（如干扰素等）杀伤病毒，细胞毒</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Times New Roman; mso-bidi-font-size: 10.5pt">T</SPAN><SPAN style="COLOR: black; FONT-FAMILY: 宋体; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt">细胞可直接杀伤病毒。</SPAN></SPAN><SPAN lang=EN-US style="COLOR: black; mso-bidi-font-size: 10.5pt"><BR></SPAN><SPAN style="FONT-SIZE: 12pt; COLOR: black; FONT-FAMILY: 宋体; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt"></SPAN></DIV>
<DIV class=MsoNormal style="MARGIN: 0cm 0cm 0pt"><SPAN style="FONT-SIZE: 12pt; COLOR: black; FONT-FAMILY: 宋体; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt"></SPAN>&nbsp;</DIV>
<DIV class=MsoNormal style="MARGIN: 0cm 0cm 0pt"><SPAN style="FONT-SIZE: 12pt; COLOR: black; FONT-FAMILY: 宋体; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt">免疫增强作用机理</SPAN><SPAN lang=EN-US style="COLOR: black; mso-bidi-font-size: 10.5pt"><BR></DIV></SPAN><SPAN style="FONT-SIZE: 12pt; COLOR: black; FONT-FAMILY: 宋体; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt"></SPAN>
<DIV class=MsoNormal style="MARGIN: 0cm 0cm 0pt"><SPAN style="FONT-SIZE: 12pt; COLOR: black; FONT-FAMILY: 宋体; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt">植物血凝素能提高骨髓造血机能，促进机体白细胞及多核白细胞明显增加，提高机体细胞诱生干扰素的功能，增加机体免疫力，促进抗体形成，增强机体对病原微生物的吞噬作用，抵抗因病毒感染造成的动物机体免疫抑制。</SPAN><SPAN lang=EN-US style="COLOR: black; mso-bidi-font-size: 10.5pt"><BR></SPAN><SPAN style="FONT-SIZE: 12pt; COLOR: black; FONT-FAMILY: 宋体; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt"></SPAN></DIV>
<DIV class=MsoNormal style="MARGIN: 0cm 0cm 0pt"><SPAN style="FONT-SIZE: 12pt; COLOR: black; FONT-FAMILY: 宋体; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt"></SPAN>&nbsp;</DIV>
<DIV class=MsoNormal style="MARGIN: 0cm 0cm 0pt"><SPAN style="FONT-SIZE: 12pt; COLOR: black; FONT-FAMILY: 宋体; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt">植物血凝素的研究应用</SPAN><SPAN lang=EN-US style="COLOR: black; mso-bidi-font-size: 10.5pt"><BR></DIV></SPAN>
<DIV class=MsoNormal style="MARGIN: 0cm 0cm 0pt"><SPAN style="FONT-SIZE: 12pt; COLOR: black; FONT-FAMILY: 宋体; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt">产品定位</SPAN><SPAN lang=EN-US style="COLOR: black; mso-bidi-font-size: 10.5pt"><BR></DIV></SPAN><SPAN style="FONT-SIZE: 12pt"><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Times New Roman; mso-bidi-font-size: 10.5pt"></SPAN></SPAN>
<DIV class=MsoNormal style="MARGIN: 0cm 0cm 0pt"><SPAN style="FONT-SIZE: 12pt"><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Times New Roman; mso-bidi-font-size: 10.5pt">1.</SPAN><SPAN style="COLOR: black; FONT-FAMILY: 宋体; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt">植物血凝素主要用于激活免疫细胞</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Times New Roman; mso-bidi-font-size: 10.5pt">———</SPAN><SPAN style="COLOR: black; FONT-FAMILY: 宋体; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt">淋巴细胞，是一种干扰素诱导剂，不仅可以刺激机体产生白介素</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Times New Roman; mso-bidi-font-size: 10.5pt">-2</SPAN><SPAN style="COLOR: black; FONT-FAMILY: 宋体; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt">和干扰素，还可以刺激机体产生非特异性抗体。</SPAN></SPAN><SPAN lang=EN-US style="COLOR: black; mso-bidi-font-size: 10.5pt"><BR></SPAN><SPAN style="FONT-SIZE: 12pt"><SPAN style="COLOR: black; FONT-FAMILY: 宋体; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt"></SPAN></SPAN></DIV>
<DIV class=MsoNormal style="MARGIN: 0cm 0cm 0pt"><SPAN style="FONT-SIZE: 12pt"><SPAN style="COLOR: black; FONT-FAMILY: 宋体; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt"></SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Times New Roman; mso-bidi-font-size: 10.5pt"></SPAN></SPAN>&nbsp;</DIV>
<DIV class=MsoNormal style="MARGIN: 0cm 0cm 0pt"><SPAN style="FONT-SIZE: 12pt"><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Times New Roman; mso-bidi-font-size: 10.5pt">2.</SPAN><SPAN style="COLOR: black; FONT-FAMILY: 宋体; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt">作为广谱抗病毒药，可用于防治家禽、家畜病毒性疾病，如鸡的传染性支气管炎、传染性喉气管炎、新城疫、传染性法氏囊、鸡痘；鸭的鸭瘟、鸭病毒性肝炎；猪的圆环病毒、猪传染性胃肠炎、猪病毒性腹泻、猪繁殖与呼吸综合征、非典型猪瘟；犬、水貂的犬瘟热、犬细小病毒等病毒性疾病。</SPAN></SPAN><SPAN lang=EN-US style="COLOR: black; mso-bidi-font-size: 10.5pt"><BR></DIV></SPAN><SPAN style="FONT-SIZE: 12pt"><SPAN style="COLOR: black; FONT-FAMILY: 宋体; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt"></SPAN></SPAN>
<DIV class=MsoNormal style="MARGIN: 0cm 0cm 0pt"><SPAN style="FONT-SIZE: 12pt"><SPAN style="COLOR: black; FONT-FAMILY: 宋体; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt"></SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Times New Roman; mso-bidi-font-size: 10.5pt">3.</SPAN><SPAN style="COLOR: black; FONT-FAMILY: 宋体; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt">作为动物免疫增强剂，可用于疾病辅助用药或用于免疫功能受损引起的疾病，用来增强动物机体免疫力，提高药物的疗效。</SPAN></SPAN><SPAN lang=EN-US style="COLOR: black; mso-bidi-font-size: 10.5pt"><BR></SPAN><SPAN style="FONT-SIZE: 12pt; COLOR: black; FONT-FAMILY: 宋体; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt"></SPAN></DIV>
<DIV class=MsoNormal style="MARGIN: 0cm 0cm 0pt"><SPAN style="FONT-SIZE: 12pt; COLOR: black; FONT-FAMILY: 宋体; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt"></SPAN>&nbsp;</DIV>
<DIV class=MsoNormal style="MARGIN: 0cm 0cm 0pt"><SPAN style="FONT-SIZE: 12pt; COLOR: black; FONT-FAMILY: 宋体; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt">特点</SPAN><SPAN lang=EN-US style="COLOR: black; mso-bidi-font-size: 10.5pt"><BR></DIV></SPAN>
<DIV class=MsoNormal style="MARGIN: 0cm 0cm 0pt"><SPAN style="FONT-SIZE: 12pt"><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Times New Roman; mso-bidi-font-size: 10.5pt">1.</SPAN><SPAN style="COLOR: black; FONT-FAMILY: 宋体; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt">使用方便、广泛，可以与许多药物同时使用，具有协同作用或相加作用。在粉散剂等许多品种药品中添加植物血凝素冻干粉，具有明显提高原有产品疗效的作用，同时不干扰原产品的检测；植物血凝素无种属特异性，可广泛在家禽、猪、牛等动物上使用。</SPAN></SPAN><SPAN lang=EN-US style="COLOR: black; mso-bidi-font-size: 10.5pt"><BR></DIV></SPAN><SPAN style="FONT-SIZE: 12pt"><SPAN style="COLOR: black; FONT-FAMILY: 宋体; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt"></SPAN></SPAN>
<DIV class=MsoNormal style="MARGIN: 0cm 0cm 0pt"><SPAN style="FONT-SIZE: 12pt"><SPAN style="COLOR: black; FONT-FAMILY: 宋体; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt"></SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Times New Roman; mso-bidi-font-size: 10.5pt">2.</SPAN><SPAN style="COLOR: black; FONT-FAMILY: 宋体; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt">使用安全，一是使用植物血凝素后不影响机体抗体水平，可用于预防肉子鸡后期常发的病毒性疾病，避免了由于加强免疫引起的抗体水平过高及疫苗应激反应；二是抗病毒谱广、毒性小、安全范围大。</SPAN></SPAN><SPAN lang=EN-US style="COLOR: black; mso-bidi-font-size: 10.5pt"><BR></SPAN><SPAN style="FONT-SIZE: 12pt"><SPAN style="COLOR: black; FONT-FAMILY: 宋体; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt"></SPAN></SPAN></DIV>
<DIV class=MsoNormal style="MARGIN: 0cm 0cm 0pt"><SPAN style="FONT-SIZE: 12pt"><SPAN style="COLOR: black; FONT-FAMILY: 宋体; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt"></SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Times New Roman; mso-bidi-font-size: 10.5pt"></SPAN></SPAN>&nbsp;</DIV>
<DIV class=MsoNormal style="MARGIN: 0cm 0cm 0pt"><SPAN style="FONT-SIZE: 12pt"><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Times New Roman; mso-bidi-font-size: 10.5pt">3.</SPAN><SPAN style="COLOR: black; FONT-FAMILY: 宋体; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt">可以与疫苗同时使用，能起到弥补免疫空白期，缓减疫苗应激反应，增强免疫效果的作用。</SPAN></SPAN><SPAN lang=EN-US style="COLOR: black; mso-bidi-font-size: 10.5pt"><BR></DIV></SPAN><SPAN style="FONT-SIZE: 12pt; COLOR: black; FONT-FAMILY: 宋体; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt"></SPAN>
<DIV class=MsoNormal style="MARGIN: 0cm 0cm 0pt"><SPAN style="FONT-SIZE: 12pt; COLOR: black; FONT-FAMILY: 宋体; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt">临床及配方推荐</SPAN><SPAN lang=EN-US style="COLOR: black; mso-bidi-font-size: 10.5pt"><BR></SPAN><SPAN style="FONT-SIZE: 12pt"><SPAN style="COLOR: black; FONT-FAMILY: 宋体; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt"></SPAN></SPAN></DIV>
<DIV class=MsoNormal style="MARGIN: 0cm 0cm 0pt"><SPAN style="FONT-SIZE: 12pt"><SPAN style="COLOR: black; FONT-FAMILY: 宋体; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt"></SPAN></SPAN>&nbsp;</DIV>
<DIV class=MsoNormal style="MARGIN: 0cm 0cm 0pt"><SPAN style="FONT-SIZE: 12pt"><SPAN style="COLOR: black; FONT-FAMILY: 宋体; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt">用于预防肉鸡常发的病毒病，</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Times New Roman; mso-bidi-font-size: 10.5pt">30</SPAN><SPAN style="COLOR: black; FONT-FAMILY: 宋体; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt">日龄左右使用</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Times New Roman; mso-bidi-font-size: 10.5pt">1</SPAN><SPAN style="COLOR: black; FONT-FAMILY: 宋体; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt">次</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Times New Roman; mso-bidi-font-size: 10.5pt">~2</SPAN><SPAN style="COLOR: black; FONT-FAMILY: 宋体; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt">次，可预防或减轻肉鸡后期病毒性疾病。</SPAN></SPAN><SPAN lang=EN-US style="COLOR: black; mso-bidi-font-size: 10.5pt"><BR></DIV></SPAN><SPAN style="FONT-SIZE: 12pt"><SPAN style="COLOR: black; FONT-FAMILY: 宋体; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt"></SPAN></SPAN>
<DIV class=MsoNormal style="MARGIN: 0cm 0cm 0pt"><SPAN style="FONT-SIZE: 12pt"><SPAN style="COLOR: black; FONT-FAMILY: 宋体; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt">用于预防子猪断奶前后病毒性疾病，与强力霉素、泰乐菌素、头孢类抗生素等合用，避免了子猪在断奶后因母乳抗体的丧失而导致免疫力下降造成的大面积发病和死亡；配合抗病毒中药（如金丝桃素、银翘散等）</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Times New Roman; mso-bidi-font-size: 10.5pt">+</SPAN><SPAN style="COLOR: black; FONT-FAMILY: 宋体; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt">广谱抗生素用于防治鸡病毒性疾病，如非典型新城疫、传染性法氏囊病初期、各型传染性支气管炎、传染性喉气管炎、鸡痘等；配合对蛋鸡生殖系统炎症有效的药物，可用于治疗蛋鸡不明原因引起的产蛋下降；配合头孢类抗生素，每月对健康蛋鸡预防一次，可有效防止蛋鸡发生病毒性疾病；也可防治猪的圆环病毒病、传染性胃肠炎、非典型猪瘟、猪繁殖与呼吸综合征、子猪断奶综合征；配合法氏囊抗体</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Times New Roman; mso-bidi-font-size: 10.5pt">+</SPAN><SPAN style="COLOR: black; FONT-FAMILY: 宋体; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt">庆大霉素（或丁胺卡那）可用于治疗急慢性法氏囊病；配合呼吸道药物，可用于防治家禽传染性支气管炎、传染性喉气管炎等病毒性呼吸道系统疾病；配合鸭病毒性肝炎血清或黄芪多糖可用于防治鸭病毒性肝炎；配合黄芪多糖</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Times New Roman; mso-bidi-font-size: 10.5pt">+</SPAN><SPAN style="COLOR: black; FONT-FAMILY: 宋体; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt">丁胺卡那，用于治疗鸭瘟。</SPAN></SPAN><SPAN lang=EN-US style="COLOR: black; mso-bidi-font-size: 10.5pt"><BR></SPAN><SPAN style="FONT-SIZE: 12pt"><SPAN style="COLOR: black; FONT-FAMILY: 宋体; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt"></SPAN></SPAN></DIV>
<DIV class=MsoNormal style="MARGIN: 0cm 0cm 0pt"><SPAN style="FONT-SIZE: 12pt"><SPAN style="COLOR: black; FONT-FAMILY: 宋体; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt"></SPAN></SPAN>&nbsp;</DIV>
<DIV class=MsoNormal style="MARGIN: 0cm 0cm 0pt"><SPAN style="FONT-SIZE: 12pt"><SPAN style="COLOR: black; FONT-FAMILY: 宋体; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt">尽管植物血凝素在兽药中有所应用，而且临床报道也显示其抗病毒作用很明显，但关于植物血凝素体内外抗病毒活性的实验室研究较少，特别是作为一种广谱抗病毒药物，植物血凝素对不同病毒的作用效果并不完全相同。今后研究的重点应放在植物血凝素对不同病毒的作用效果研究上。由于其强大的免疫增强作用，我们还可以尝试去开发一种</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Times New Roman; mso-bidi-font-size: 10.5pt">“</SPAN><SPAN style="COLOR: black; FONT-FAMILY: 宋体; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt">超级免疫增强剂</SPAN><SPAN lang=EN-US style="COLOR: black; FONT-FAMILY: Times New Roman; mso-bidi-font-size: 10.5pt">”</SPAN><SPAN style="COLOR: black; FONT-FAMILY: 宋体; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-bidi-font-size: 10.5pt">，即对多种免疫增强剂进行不同的配伍筛选。如同为干扰素诱生剂，刺五加诱生干扰素的机理与植物血凝素诱生干扰素的机理不同，两者配伍可以增强对干扰素的诱生效果。此外由于植物血凝素提取工艺的复杂性决定了其生产成本较高，如能开发出一种更加经济有效的提取工艺，必然会大大促进植物血凝素在兽药中的应用。总之，随着相关研究的不断深入，植物血凝素抗病毒、增强免疫作用以及其他药用潜力将会被不断挖掘，其应用前景将十分广阔。</SPAN></SPAN></DIV></SPAN></TD></TR></TBODY></TABLE>

jinmingbi6

现在已普遍接受，不过价格好像不便宜啊。